Analysis of constitutions by mathematical principles. II. The analysis of intimal arteriosclerotic constitutions.

Certain aspects of the etiology of the intimal arteriosclerosis were discussed by the development of the mathematical structure of an organism previously proposed. One school supposed that an essential factor for intimal arteriosclerosis was glycoprotein, but not lipid. The abnormal deposition of glycoprotein into the intima of arteries and the subendotherial space of capillaries might take place only when glycoprotein was excessively synthesized in the liver more than the requirements of an organism. The metabolic tendency mentioned above arises from both elements in set X of genetic factors and in set Y of environmental factors. It was explained that as for the elements in set Y, there were high fat diet, low protein diet. and pyridoxine deficient diet, while as the elements in set X hereditary deficiencies of hepatic key glycolytic enzymes were considered. A common element in set Z of vital phenomena derived from above mentioned ele· ments, is the use of fatty acids as main source of energy in the liver which, in turn, spares both protein and glucides and scarcely uses glycolytic pathway for energy production. Although elements in set X always predominate over elements in set Yin intimal arteriosclerosis, the stronger the elements of both set X and set Y have tendencies to suffer from this disease, the shorter the time factor t for onset of this disease will be. Even if all elements in set X are normal, one has to re· frain from overeating in older age when he needs less energy and protein per kg body weight per day compared with the younger.